Partial Biopterin Deficiency Disturbs Postnatal Development of the Dopaminergic System in the Brain

Postnatal development of dopaminergic system is closely related to the development of psychomotor function. Tyrosine hydroxylase (TH) is the rate-limiting enzyme in the biosynthesis of dopamine and requires tetrahydrobiopterin (BH4) as a cofactor. To clarify the effect of partial BH4 deficiency on p...

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Библиографические подробности
Главные авторы: Homma, Daigo, Sumi-Ichinose, Chiho, Tokuoka, Hirofumi, Ikemoto, Kazuhisa, Nomura, Takahide, Kondo, Kazunao, Katoh, Setsuko, Ichinose, Hiroshi
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Biochemistry and Molecular Biology 2011
Предметы:
Neurobiology
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3020753/
https://ncbi.nlm.nih.gov/pubmed/21062748
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.159426
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