Sepiapterin reductase gene‐disrupted mice suffer from hypertension with fluctuation and bradycardia

(6R)‐l‐erythro‐5,6,7,8‐Tetrahydrobiopterin (BH4) is an essential cofactor for monoamine and nitric oxide (NO) production. Sepiapterin reductase (SPR) catalyzes the final step in BH4 biosynthesis. We analyzed the cardiovascular function of adult Spr gene‐disrupted (Spr (−/−)) mice for the first time....

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Publicat a:Physiol Rep
Autors principals: Sumi‐Ichinose, Chiho, Suganuma, Yui, Kano, Taiki, Ihira, Noriko, Nomura, Hiroko, Ikemoto, Kazuhisa, Hata, Tadayoshi, Katoh, Setsuko, Ichinose, Hiroshi, Kondo, Kazunao
Format: Artigo
Idioma:Inglês
Publicat: John Wiley and Sons Inc. 2017
Matèries:
Original Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5371564/
https://ncbi.nlm.nih.gov/pubmed/28320892
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.14814/phy2.13196
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