GABA(B) receptor allosteric modulators exhibit pathway‐dependent and species‐selective activity

Positive modulation of the GABA(B) receptor (GABA(B)R) represents a potentially useful therapeutic approach for the treatment of nicotine addiction. The positive allosteric modulators (PAMs) of GABA(B)R GS39783 and BHF177 enhance GABA‐stimulated [(35)S]GTP γS‐binding, and have shown efficacy in a ro...

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Detalhes bibliográficos
Publicado no:Pharmacol Res Perspect
Main Authors: Sturchler, Emmanuel, Li, Xia, de Lourdes Ladino, Maria, Kaczanowska, Kasia, Cameron, Michael, Griffin, Patrick R., Finn, M. G., Markou, Athina, McDonald, Patricia
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2017
Assuntos:
Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5368958/
https://ncbi.nlm.nih.gov/pubmed/28357120
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/prp2.288
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