Comparison of the effects of the GABA(B) receptor positive modulator BHF177 and the GABA(B) receptor agonist baclofen on anxiety-like behavior, learning, and memory in mice

γ-Aminobutyric acid B (GABA(B)) receptor activation is a potential therapeutic approach for the treatment of drug addiction, pain, anxiety, and depression. However, full agonists of this receptor induce side-effects, such as sedation, muscle relaxation, tolerance, and cognitive disruption. Positive...

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Autori principali: Li, Xia, Risbrough, Victoria B., Cates-Gatto, Chelsea, Kaczanowska, Katarzyna, Finn, M. G., Roberts, Amanda J, Markou, Athina
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2013
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3644349/
https://ncbi.nlm.nih.gov/pubmed/23376712
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuropharm.2013.01.018
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