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Conditional Deletion of the Phd2 Gene in Articular Chondrocytes Accelerates Differentiation and Reduces Articular Cartilage Thickness

Based on our findings that PHD2 is a negative regulator of chondrocyte differentiation and that hypoxia signaling is implicated in the pathogenesis of osteoarthritis, we investigated the consequence of disruption of the Phd2 gene in chondrocytes on the articular cartilage phenotype in mice. Immunohi...

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Vydáno v:Sci Rep
Hlavní autoři: Cheng, Shaohong, Pourteymoor, Sheila, Alarcon, Catrina, Mohan, Subburaman
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2017
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5368651/
https://ncbi.nlm.nih.gov/pubmed/28349987
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep45408
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