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Conditional Deletion of the Phd2 Gene in Articular Chondrocytes Accelerates Differentiation and Reduces Articular Cartilage Thickness

Based on our findings that PHD2 is a negative regulator of chondrocyte differentiation and that hypoxia signaling is implicated in the pathogenesis of osteoarthritis, we investigated the consequence of disruption of the Phd2 gene in chondrocytes on the articular cartilage phenotype in mice. Immunohi...

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Détails bibliographiques
Publié dans:Sci Rep
Auteurs principaux: Cheng, Shaohong, Pourteymoor, Sheila, Alarcon, Catrina, Mohan, Subburaman
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group 2017
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5368651/
https://ncbi.nlm.nih.gov/pubmed/28349987
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep45408
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