Conditional Deletion of Prolyl Hydroxylase Domain-Containing Protein 2 (Phd2) Gene Reveals Its Essential Role in Chondrocyte Function and Endochondral Bone Formation

The hypoxic growth plate cartilage requires hypoxia-inducible factor (HIF)-mediated pathways to maintain chondrocyte survival and differentiation. HIF proteins are tightly regulated by prolyl hydroxylase domain-containing protein 2 (Phd2)-mediated proteosomal degradation. We conditionally disrupted...

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Vydáno v:Endocrinology
Hlavní autoři: Cheng, Shaohong, Xing, Weirong, Pourteymoor, Sheila, Schulte, Jan, Mohan, Subburaman
Médium: Artigo
Jazyk:Inglês
Vydáno: Endocrine Society 2016
Témata:
Original Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4701886/
https://ncbi.nlm.nih.gov/pubmed/26562260
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/en.2015-1473
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