Systemic Delivery of Tumor-Targeted Bax-Derived Membrane-Active Peptides for the Treatment of Melanoma Tumors in a Humanized SCID Mouse Model

Melanoma is a highly metastatic and deadly form of cancer. Invasive melanoma cells overexpress integrin α(v)β(3), which is a well-known target for Arg-Gly-Asp-based (RGD) peptides. We developed a sophisticated method to synthetize milligram amounts of a targeted vector that allows the RGD-mediated t...

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Veröffentlicht in:Mol Ther
Hauptverfasser: Karageorgis, Anastassia, Claron, Michaël, Jugé, Romain, Aspord, Caroline, Thoreau, Fabien, Leloup, Claire, Kucharczak, Jérôme, Plumas, Joël, Henry, Maxime, Hurbin, Amandine, Verdié, Pascal, Martinez, Jean, Subra, Gilles, Dumy, Pascal, Boturyn, Didier, Aouacheria, Abdel, Coll, Jean-Luc
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society of Gene & Cell Therapy 2017
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Original Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5368406/
https://ncbi.nlm.nih.gov/pubmed/28153100
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ymthe.2016.11.002
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