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Systemic Delivery of Tumor-Targeted Bax-Derived Membrane-Active Peptides for the Treatment of Melanoma Tumors in a Humanized SCID Mouse Model
Melanoma is a highly metastatic and deadly form of cancer. Invasive melanoma cells overexpress integrin α(v)β(3), which is a well-known target for Arg-Gly-Asp-based (RGD) peptides. We developed a sophisticated method to synthetize milligram amounts of a targeted vector that allows the RGD-mediated t...
שמור ב:
| הוצא לאור ב: | Mol Ther |
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| Main Authors: | , , , , , , , , , , , , , , , , |
| פורמט: | Artigo |
| שפה: | Inglês |
| יצא לאור: |
American Society of Gene & Cell Therapy
2017
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| נושאים: | |
| גישה מקוונת: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5368406/ https://ncbi.nlm.nih.gov/pubmed/28153100 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ymthe.2016.11.002 |
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