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Cyclized Oligopeptide Targeting LRP5/6-DKK1 Interaction Reduces the Growth of Tumor Burden in a Multiple Myeloma Mouse Model

PURPOSE: Dickkopf 1 (DKK1) has been extensively investigated in mouse models of multiple myeloma, which results in osteolytic bone lesions. Elevated DKK1 levels in bone marrow plasma and serum inhibit the differentiation of osteoblast precursors. Present pharmaceutical approaches to target bone lesi...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
में प्रकाशित:Yonsei Med J
मुख्य लेखकों: Park, Bo Mi, Kim, Eun Jin, Nam, Hee Jin, Zhang, Dongdong, Bae, Chu Hyun, Kang, Myeongmo, Kim, Heeyoun, Lee, Weontae, Bogen, Bjarne, Lim, Sung-Kil
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: Yonsei University College of Medicine 2017
विषय:
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC5368134/
https://ncbi.nlm.nih.gov/pubmed/28332354
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3349/ymj.2017.58.3.505
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