Cyclized Oligopeptide Targeting LRP5/6-DKK1 Interaction Reduces the Growth of Tumor Burden in a Multiple Myeloma Mouse Model

PURPOSE: Dickkopf 1 (DKK1) has been extensively investigated in mouse models of multiple myeloma, which results in osteolytic bone lesions. Elevated DKK1 levels in bone marrow plasma and serum inhibit the differentiation of osteoblast precursors. Present pharmaceutical approaches to target bone lesi...

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Detalhes bibliográficos
Publicado no:Yonsei Med J
Main Authors: Park, Bo Mi, Kim, Eun Jin, Nam, Hee Jin, Zhang, Dongdong, Bae, Chu Hyun, Kang, Myeongmo, Kim, Heeyoun, Lee, Weontae, Bogen, Bjarne, Lim, Sung-Kil
Formato: Artigo
Idioma:Inglês
Publicado em: Yonsei University College of Medicine 2017
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5368134/
https://ncbi.nlm.nih.gov/pubmed/28332354
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3349/ymj.2017.58.3.505
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