Cyclized Oligopeptide Targeting LRP5/6-DKK1 Interaction Reduces the Growth of Tumor Burden in a Multiple Myeloma Mouse Model

PURPOSE: Dickkopf 1 (DKK1) has been extensively investigated in mouse models of multiple myeloma, which results in osteolytic bone lesions. Elevated DKK1 levels in bone marrow plasma and serum inhibit the differentiation of osteoblast precursors. Present pharmaceutical approaches to target bone lesi...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Yonsei Med J
Main Authors: Park, Bo Mi, Kim, Eun Jin, Nam, Hee Jin, Zhang, Dongdong, Bae, Chu Hyun, Kang, Myeongmo, Kim, Heeyoun, Lee, Weontae, Bogen, Bjarne, Lim, Sung-Kil
Format: Artigo
Jezik:Inglês
Izdano: Yonsei University College of Medicine 2017
Teme:
Original Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5368134/
https://ncbi.nlm.nih.gov/pubmed/28332354
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3349/ymj.2017.58.3.505
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