Cyclized Oligopeptide Targeting LRP5/6-DKK1 Interaction Reduces the Growth of Tumor Burden in a Multiple Myeloma Mouse Model

PURPOSE: Dickkopf 1 (DKK1) has been extensively investigated in mouse models of multiple myeloma, which results in osteolytic bone lesions. Elevated DKK1 levels in bone marrow plasma and serum inhibit the differentiation of osteoblast precursors. Present pharmaceutical approaches to target bone lesi...

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Pubblicato in:Yonsei Med J
Autori principali: Park, Bo Mi, Kim, Eun Jin, Nam, Hee Jin, Zhang, Dongdong, Bae, Chu Hyun, Kang, Myeongmo, Kim, Heeyoun, Lee, Weontae, Bogen, Bjarne, Lim, Sung-Kil
Natura: Artigo
Lingua:Inglês
Pubblicazione: Yonsei University College of Medicine 2017
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Original Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5368134/
https://ncbi.nlm.nih.gov/pubmed/28332354
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3349/ymj.2017.58.3.505
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