Cyclized Oligopeptide Targeting LRP5/6-DKK1 Interaction Reduces the Growth of Tumor Burden in a Multiple Myeloma Mouse Model

PURPOSE: Dickkopf 1 (DKK1) has been extensively investigated in mouse models of multiple myeloma, which results in osteolytic bone lesions. Elevated DKK1 levels in bone marrow plasma and serum inhibit the differentiation of osteoblast precursors. Present pharmaceutical approaches to target bone lesi...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Yonsei Med J
Egile Nagusiak: Park, Bo Mi, Kim, Eun Jin, Nam, Hee Jin, Zhang, Dongdong, Bae, Chu Hyun, Kang, Myeongmo, Kim, Heeyoun, Lee, Weontae, Bogen, Bjarne, Lim, Sung-Kil
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Yonsei University College of Medicine 2017
Gaiak:
Original Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC5368134/
https://ncbi.nlm.nih.gov/pubmed/28332354
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3349/ymj.2017.58.3.505
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