PACMANS: A bioinformatically informed algorithm to predict, design, and disrupt protease‐on‐protease hydrolysis

Multiple proteases in a system hydrolyze target substrates, but recent evidence indicates that some proteases will degrade other proteases as well. Cathepsin S hydrolysis of cathepsin K is one such example. These interactions may be uni‐ or bi‐directional and change the expected kinetics. To explore...

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Bibliographic Details
Published in:Protein Sci
Main Authors: Ferrall‐Fairbanks, Meghan C., Barry, Zachary T., Affer, Maurizio, Shuler, Marc A., Moomaw, Ellen W., Platt, Manu O.
Format: Artigo
Language:Inglês
Published: John Wiley and Sons Inc. 2017
Subjects:
Methods and Applications
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5368069/
https://ncbi.nlm.nih.gov/pubmed/28078782
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pro.3113
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