Pharmacological inhibition of complement C5a‐C5a(1) receptor signalling ameliorates disease pathology in the hSOD1(G93A) mouse model of amyotrophic lateral sclerosis

BACKGROUND AND PURPOSE: Amyotrophic lateral sclerosis (ALS) is a fatal and rapidly progressing motor neuron disease without effective treatment. The complement system is up‐regulated in ALS, with recent studies indicating that the activation product C5a accelerates disease progression via the C5a(1)...

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Detaylı Bibliyografya
Yayımlandı:Br J Pharmacol
Asıl Yazarlar: Lee, John D, Kumar, Vinod, Fung, Jenny N T, Ruitenberg, Marc J, Noakes, Peter G, Woodruff, Trent M
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: John Wiley and Sons Inc. 2017
Konular:
Research Papers
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5368046/
https://ncbi.nlm.nih.gov/pubmed/28128456
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.13730
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