Pharmacological inhibition of complement C5a‐C5a(1) receptor signalling ameliorates disease pathology in the hSOD1(G93A) mouse model of amyotrophic lateral sclerosis

BACKGROUND AND PURPOSE: Amyotrophic lateral sclerosis (ALS) is a fatal and rapidly progressing motor neuron disease without effective treatment. The complement system is up‐regulated in ALS, with recent studies indicating that the activation product C5a accelerates disease progression via the C5a(1)...

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Bibliographische Detailangaben
Veröffentlicht in:Br J Pharmacol
Hauptverfasser: Lee, John D, Kumar, Vinod, Fung, Jenny N T, Ruitenberg, Marc J, Noakes, Peter G, Woodruff, Trent M
Format: Artigo
Sprache:Inglês
Veröffentlicht: John Wiley and Sons Inc. 2017
Schlagworte:
Research Papers
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5368046/
https://ncbi.nlm.nih.gov/pubmed/28128456
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.13730
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