Complement C5a-C5aR1 signalling drives skeletal muscle macrophage recruitment in the hSOD1(G93A) mouse model of amyotrophic lateral sclerosis

BACKGROUND: The terminal pathway of the innate immune complement system is implicated in the pathogenesis of amyotrophic lateral sclerosis (ALS). Terminal complement activation leads to generation of C5a, which through its receptor, C5aR1, drives immune cell recruitment and activation. Importantly,...

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Bibliographic Details
Published in:Skelet Muscle
Main Authors: Wang, Haitao A., Lee, John D., Lee, Kah Meng, Woodruff, Trent M., Noakes, Peter G.
Format: Artigo
Language:Inglês
Published: BioMed Central 2017
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Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5455206/
https://ncbi.nlm.nih.gov/pubmed/28571586
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13395-017-0128-8
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