Complement C5a-C5aR1 signalling drives skeletal muscle macrophage recruitment in the hSOD1(G93A) mouse model of amyotrophic lateral sclerosis

BACKGROUND: The terminal pathway of the innate immune complement system is implicated in the pathogenesis of amyotrophic lateral sclerosis (ALS). Terminal complement activation leads to generation of C5a, which through its receptor, C5aR1, drives immune cell recruitment and activation. Importantly,...

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Détails bibliographiques
Publié dans:Skelet Muscle
Auteurs principaux: Wang, Haitao A., Lee, John D., Lee, Kah Meng, Woodruff, Trent M., Noakes, Peter G.
Format: Artigo
Langue:Inglês
Publié: BioMed Central 2017
Sujets:
Research
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5455206/
https://ncbi.nlm.nih.gov/pubmed/28571586
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13395-017-0128-8
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