Complement C5a-C5aR1 signalling drives skeletal muscle macrophage recruitment in the hSOD1(G93A) mouse model of amyotrophic lateral sclerosis

BACKGROUND: The terminal pathway of the innate immune complement system is implicated in the pathogenesis of amyotrophic lateral sclerosis (ALS). Terminal complement activation leads to generation of C5a, which through its receptor, C5aR1, drives immune cell recruitment and activation. Importantly,...

Popoln opis

Shranjeno v:
Bibliografske podrobnosti
izdano v:Skelet Muscle
Main Authors: Wang, Haitao A., Lee, John D., Lee, Kah Meng, Woodruff, Trent M., Noakes, Peter G.
Format: Artigo
Jezik:Inglês
Izdano: BioMed Central 2017
Teme:
Research
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5455206/
https://ncbi.nlm.nih.gov/pubmed/28571586
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13395-017-0128-8
Oznake: Označite
Brez oznak, prvi označite!

Podobne knjige/članki