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Parameter estimation for multistage clonal expansion models from cancer incidence data: A practical identifiability analysis
Many cancers are understood to be the product of multiple somatic mutations or other rate-limiting events. Multistage clonal expansion (MSCE) models are a class of continuous-time Markov chain models that capture the multi-hit initiation–promotion–malignant-conversion hypothesis of carcinogenesis. T...
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| Publicado no: | PLoS Comput Biol |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Public Library of Science
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5367820/ https://ncbi.nlm.nih.gov/pubmed/28288156 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1005431 |
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