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Parameter estimation for multistage clonal expansion models from cancer incidence data: A practical identifiability analysis.
Many cancers are understood to be the product of multiple somatic mutations or other rate-limiting events. Multistage clonal expansion (MSCE) models are a class of continuous-time Markov chain models that capture the multi-hit initiation-promotion-malignant-conversion hypothesis of carcinogenesis. T...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Public Library of Science (PLoS)
2017-03-01
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| Colecção: | PLoS Computational Biology |
| Acesso em linha: | http://europepmc.org/articles/PMC5367820?pdf=render |
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