Small molecule inhibitor of NRF2 selectively intervenes therapeutic resistance in KEAP1-deficient NSCLC tumors

Loss of function mutations in Kelch Like ECH Associated Protein 1 (KEAP1) or gain-of-function mutations in nuclear factor erythroid 2-related factor 2 (NRF2) are common in non-small cell lung cancer (NSCLC) and is associated with therapeutic resistance. To discover novel NRF2 inhibitors for targeted...

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Pubblicato in:ACS Chem Biol
Autori principali: Singh, Anju, Venkannagari, Sreedhar, Oh, Kyu H., Zhang, Ya-Qin, Rohde, Jason M., Liu, Li, Nimmagadda, Sridhar, Sudini, Kuladeep, Brimacombe, Kyle R., Gajghate, Sachin, Ma, Jinfang, Wang, Amy, Xu, Xin, Shahane, Sampada A., Xia, Menghang, Woo, Juhyung, Mensah, George A., Wang, Zhibin, Ferrer, Marc, Gabrielson, Edward, Li, Zhuyin, Rastinejad, Fraydoon, Shen, Min, Boxer, Matthew B., Biswal, Shyam
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2016
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5367156/
https://ncbi.nlm.nih.gov/pubmed/27552339
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschembio.6b00651
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