Small molecule inhibitor of NRF2 selectively intervenes therapeutic resistance in KEAP1-deficient NSCLC tumors

Loss of function mutations in Kelch Like ECH Associated Protein 1 (KEAP1) or gain-of-function mutations in nuclear factor erythroid 2-related factor 2 (NRF2) are common in non-small cell lung cancer (NSCLC) and is associated with therapeutic resistance. To discover novel NRF2 inhibitors for targeted...

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Publicado en:ACS Chem Biol
Main Authors: Singh, Anju, Venkannagari, Sreedhar, Oh, Kyu H., Zhang, Ya-Qin, Rohde, Jason M., Liu, Li, Nimmagadda, Sridhar, Sudini, Kuladeep, Brimacombe, Kyle R., Gajghate, Sachin, Ma, Jinfang, Wang, Amy, Xu, Xin, Shahane, Sampada A., Xia, Menghang, Woo, Juhyung, Mensah, George A., Wang, Zhibin, Ferrer, Marc, Gabrielson, Edward, Li, Zhuyin, Rastinejad, Fraydoon, Shen, Min, Boxer, Matthew B., Biswal, Shyam
Formato: Artigo
Idioma:Inglês
Publicado: 2016
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5367156/
https://ncbi.nlm.nih.gov/pubmed/27552339
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschembio.6b00651
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