Can Ceftazidime-Avibactam and Aztreonam Overcome β-Lactam Resistance Conferred by Metallo-β-Lactamases in Enterobacteriaceae?

Based upon knowledge of the hydrolytic profile of major β-lactamases found in Gram-negative bacteria, we tested the efficacy of the combination of ceftazidime-avibactam (CAZ-AVI) with aztreonam (ATM) against carbapenem-resistant enteric bacteria possessing metallo-β-lactamases (MBLs). Disk diffusion...

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Pubblicato in:Antimicrob Agents Chemother
Autori principali: Marshall, Steven, Hujer, Andrea M., Rojas, Laura J., Papp-Wallace, Krisztina M., Humphries, Romney M., Spellberg, Brad, Hujer, Kristine M., Marshall, Emma K., Rudin, Susan D., Perez, Federico, Wilson, Brigid M., Wasserman, Ronald B., Chikowski, Linda, Paterson, David L., Vila, Alejandro J., van Duin, David, Kreiswirth, Barry N., Chambers, Henry F., Fowler, Vance G., Jacobs, Michael R., Pulse, Mark E., Weiss, William J., Bonomo, Robert A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2017
Soggetti:
Susceptibility
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5365724/
https://ncbi.nlm.nih.gov/pubmed/28167541
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.02243-16
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