Can Ceftazidime-Avibactam and Aztreonam Overcome β-Lactam Resistance Conferred by Metallo-β-Lactamases in Enterobacteriaceae?

Based upon knowledge of the hydrolytic profile of major β-lactamases found in Gram-negative bacteria, we tested the efficacy of the combination of ceftazidime-avibactam (CAZ-AVI) with aztreonam (ATM) against carbapenem-resistant enteric bacteria possessing metallo-β-lactamases (MBLs). Disk diffusion...

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發表在:Antimicrob Agents Chemother
Main Authors: Marshall, Steven, Hujer, Andrea M., Rojas, Laura J., Papp-Wallace, Krisztina M., Humphries, Romney M., Spellberg, Brad, Hujer, Kristine M., Marshall, Emma K., Rudin, Susan D., Perez, Federico, Wilson, Brigid M., Wasserman, Ronald B., Chikowski, Linda, Paterson, David L., Vila, Alejandro J., van Duin, David, Kreiswirth, Barry N., Chambers, Henry F., Fowler, Vance G., Jacobs, Michael R., Pulse, Mark E., Weiss, William J., Bonomo, Robert A.
格式: Artigo
語言:Inglês
出版: American Society for Microbiology 2017
主題:
Susceptibility
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC5365724/
https://ncbi.nlm.nih.gov/pubmed/28167541
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.02243-16
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