CancerLocator: non-invasive cancer diagnosis and tissue-of-origin prediction using methylation profiles of cell-free DNA

We propose a probabilistic method, CancerLocator, which exploits the diagnostic potential of cell-free DNA by determining not only the presence but also the location of tumors. CancerLocator simultaneously infers the proportions and the tissue-of-origin of tumor-derived cell-free DNA in a blood samp...

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Dades bibliogràfiques
Publicat a:Genome Biol
Autors principals: Kang, Shuli, Li, Qingjiao, Chen, Quan, Zhou, Yonggang, Park, Stacy, Lee, Gina, Grimes, Brandon, Krysan, Kostyantyn, Yu, Min, Wang, Wei, Alber, Frank, Sun, Fengzhu, Dubinett, Steven M., Li, Wenyuan, Zhou, Xianghong Jasmine
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2017
Matèries:
Method
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5364586/
https://ncbi.nlm.nih.gov/pubmed/28335812
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13059-017-1191-5
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