Poly lactic-co-glycolic acid controlled delivery of disulfiram to target liver cancer stem-like cells

Disulfiram (DS), an anti-alcoholism drug, shows very strong cytotoxicity in many cancer types. However its clinical application in cancer treatment is limited by the very short half-life in the bloodstream. In this study, we developed a poly lactic-co-glycolic acid (PLGA)-encapsulated DS protecting...

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Detalhes bibliográficos
Publicado no:Nanomedicine
Main Authors: Wang, Zhipeng, Tan, Jiao, McConville, Christopher, Kannappan, Vinodh, Tawari, Patricia Erebi, Brown, James, Ding, Jin, Armesilla, Angel L., Irache, Juan M., Mei, Qi-Bing, Tan, Yuhuan, Liu, Ying, Jiang, Wenguo, Bian, Xiu-Wu, Wang, Weiguang
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2017
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5364371/
https://ncbi.nlm.nih.gov/pubmed/27521693
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nano.2016.08.001
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