Myeloid Cell-Specific Knockout of NFI-A Improves Sepsis Survival

Myeloid progenitor-derived suppressor cells (MDSCs) arise from myeloid progenitors and suppress both innate and adaptive immunity. MDSCs expand during the later phases of sepsis in mice, promote immunosuppression, and reduce survival. Here, we report that the myeloid differentiation-related transcri...

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Veröffentlicht in:Infect Immun
Hauptverfasser: McPeak, Melissa B., Youssef, Dima, Williams, Danielle A., Pritchett, Christopher, Yao, Zhi Q., McCall, Charles E., El Gazzar, Mohamed
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2017
Schlagworte:
Host Response and Inflammation
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5364314/
https://ncbi.nlm.nih.gov/pubmed/28167668
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.00066-17
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