MicroRNA 21 (miR-21) and miR-181b Couple with NFI-A To Generate Myeloid-Derived Suppressor Cells and Promote Immunosuppression in Late Sepsis

The sepsis initial hyperinflammatory reaction, if not treated early, shifts to a protracted state of immunosuppression that alters both innate and adaptive immunity and is associated with elevated mortality. Myeloid-derived suppressor cells (MDSCs) are myeloid progenitors and precursors that fail to...

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Autores principales: McClure, Clara, Brudecki, Laura, Ferguson, Donald A., Yao, Zhi Q., Moorman, Jonathan P., McCall, Charles E., El Gazzar, Mohamed
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology 2014
Materias:
Host Response and Inflammation
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4187818/
https://ncbi.nlm.nih.gov/pubmed/24980967
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.01495-14
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