Bioconjugation of Small Molecules to RNA Impedes Its Recognition by Toll-Like Receptor 7

A fundamental mechanism of the innate immune system is the recognition, via extra- and intracellular pattern-recognition receptors, of pathogen-associated molecular patterns. A prominent example is represented by foreign nucleic acids, triggering the activation of several signaling pathways. Among t...

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Bibliographische Detailangaben
Veröffentlicht in:Front Immunol
Hauptverfasser: Hellmuth, Isabell, Freund, Isabel, Schlöder, Janine, Seidu-Larry, Salifu, Thüring, Kathrin, Slama, Kaouthar, Langhanki, Jens, Kaloyanova, Stefka, Eigenbrod, Tatjana, Krumb, Matthias, Röhm, Sandra, Peneva, Kalina, Opatz, Till, Jonuleit, Helmut, Dalpke, Alexander H., Helm, Mark
Format: Artigo
Sprache:Inglês
Veröffentlicht: Frontiers Media S.A. 2017
Schlagworte:
Immunology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5364167/
https://ncbi.nlm.nih.gov/pubmed/28392787
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2017.00312
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