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A modified dinucleotide motif specifies tRNA recognition by TLR7

RNA can function as a pathogen-associated molecular pattern (PAMP) whose recognition by the innate immune system alerts the body to an impending microbial infection. The recognition of tRNA as either self or nonself RNA by TLR7 depends on its modification patterns. In particular, it is known that th...

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Detalhes bibliográficos
Main Authors: Kaiser, Steffen, Rimbach, Katharina, Eigenbrod, Tatjana, Dalpke, Alexander H., Helm, Mark
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4138318/
https://ncbi.nlm.nih.gov/pubmed/25051971
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1261/rna.044024.113
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