2'-O-Methylation within Bacterial RNA Acts as Suppressor of TLR7/TLR8 Activation in Human Innate Immune Cells

Microbial RNA is an important stimulator of innate immune responses. Differences in posttranscriptional RNA modification profiles enable the immune system to discriminate between self and non-self nucleic acids. This principle may be exploited by certain bacteria to circumvent immune cell activation...

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Udgivet i:J Innate Immun
Main Authors: Rimbach, Katharina, Kaiser, Steffen, Helm, Mark, Dalpke, Alexander H., Eigenbrod, Tatjana
Format: Artigo
Sprog:Inglês
Udgivet: S. Karger AG 2015
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6738864/
https://ncbi.nlm.nih.gov/pubmed/25823462
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1159/000375460
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