Identification of modifications in microbial, native tRNA that suppress immunostimulatory activity

Naturally occurring nucleotide modifications within RNA have been proposed to be structural determinants for innate immune recognition. We tested this hypothesis in the context of native nonself-RNAs. Isolated, fully modified native bacterial transfer RNAs (tRNAs) induced significant secretion of IF...

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Autori principali: Gehrig, Stefanie, Eberle, Mariel-Esther, Botschen, Flavia, Rimbach, Katharina, Eberle, Florian, Eigenbrod, Tatjana, Kaiser, Steffen, Holmes, Walter M., Erdmann, Volker A., Sprinzl, Mathias, Bec, Guillaume, Keith, Gérard, Dalpke, Alexander H., Helm, Mark
Natura: Artigo
Lingua:Inglês
Pubblicazione: The Rockefeller University Press 2012
Soggetti:
Brief Definitive Report
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3280868/
https://ncbi.nlm.nih.gov/pubmed/22312113
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20111044
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