Celastrol ameliorates Cd-induced neuronal apoptosis by targeting NOX2-derived ROS-dependent PP5-JNK signaling pathway

Celastrol, a plant-derived triterpene, has neuroprotective benefit in the models of neurodegenerative disorders that are characterized by overproduction of reactive oxygen species (ROS). Recently, we have reported that cadmium (Cd) activates c-Jun N-terminal kinase (JNK) pathway leading to neuronal...

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Detalhes bibliográficos
Publicado no:J Neurochem
Main Authors: Xu, Chong, Wang, Xiaoxue, Gu, Chenjian, Zhang, Hai, Zhang, Ruijie, Dong, Xiaoqing, Liu, Chunxiao, Hu, Xiaoyu, Ji, Xiang, Huang, Shile, Chen, Long
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5364082/
https://ncbi.nlm.nih.gov/pubmed/28129433
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/jnc.13966
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