NLRP3–caspase-1 Inflammasome Degrades Contractile Proteins: Implications for Aortic Biomechanical Dysfunction and Aneurysm and Dissection Formation

OBJECTIVE: —Increasing evidence suggests that contractile dysfunction in smooth muscle cells (SMCs) plays a critical role in aortic biomechanical dysfunction and aortic aneurysm and dissection (AAD) development. However, the mechanisms underlying SMC contractile dysfunction in sporadic AAD are poorl...

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Gepubliceerd in:Arterioscler Thromb Vasc Biol
Hoofdauteurs: Wu, Darrell, Ren, Pingping, Zheng, Yanqiu, Zhang, Lin, Xu, Gaiping, Xie, Wanmu, Lloyd, Eric E., Zhang, Sui, Zhang, Qianzi, Curci, John A., Coselli, Joseph S., Milewicz, Dianna M., Shen, Ying H., LeMaire, Scott A.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2017
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5364046/
https://ncbi.nlm.nih.gov/pubmed/28153878
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/ATVBAHA.116.307648
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