Critical Role of ADAMTS-4 in the Development of Sporadic Aortic Aneurysm and Dissection in Mice

Sporadic aortic aneurysm and dissections (AADs) are common vascular diseases that carry a high mortality rate. ADAMTS-4 (a disintegrin-like and metalloproteinase with thrombospondin motifs-4) is a secreted proteinase involved in inflammation and matrix degradation. We previously showed ADAMTS-4 leve...

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Udgivet i:Sci Rep
Main Authors: Ren, Pingping, Hughes, Michael, Krishnamoorthy, Swapna, Zou, Sili, Zhang, Lin, Wu, Darrell, Zhang, Chen, Curci, John A., Coselli, Joseph S., Milewicz, Dianna M., LeMaire, Scott A., Shen, Ying H.
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5617887/
https://ncbi.nlm.nih.gov/pubmed/28955046
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-12248-z
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