Synthesis and bioevaluation of N,4-diaryl-1,3-thiazole-2-amines as tubulin inhibitors with potent antiproliferative activity

A series of N,4-diaryl-1,3-thiazole-2-amines containing three aromatic rings with an amino linker were designed and synthesized as tubulin inhibitors and evaluated for their antiproliferative activity in three human cancer cell lines. Most of the target compounds displayed moderate antiproliferative...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Sun, Maolin, Xu, Qile, Xu, Jingwen, Wu, Yue, Wang, Yueting, Zuo, Daiying, Guan, Qi, Bao, Kai, Wang, Jian, Wu, Yingliang, Zhang, Weige
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2017
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5363846/
https://ncbi.nlm.nih.gov/pubmed/28333984
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0174006
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