Synthesis and Bioevaluation of 3,6-Diaryl-[1,2,4]triazolo[4,3-b] Pyridazines as Antitubulin Agents

[Image: see text] A series of 3,6-diaryl-[1,2,4]triazolo[4,3-b]pyridazines were designed as a class of vinylogous CA-4 analogues. The easily isomerized (Z,E)-butadiene linker of vinylogous CA-4 was replaced by a rigid [1,2,4]triazolo[4,3-b]pyridazine scaffold. Twenty-one target compounds were synthe...

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Publicado en:ACS Med Chem Lett
Autores principales: Xu, Qile, Wang, Yueting, Xu, Jingwen, Sun, Maolin, Tian, Haiqiu, Zuo, Daiying, Guan, Qi, Bao, Kai, Wu, Yingliang, Zhang, Weige
Formato: Artigo
Lenguaje:Inglês
Publicado: American Chemical Society 2016
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5150690/
https://ncbi.nlm.nih.gov/pubmed/27994764
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.6b00252
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