Synthesis and bioevaluation of N,4-diaryl-1,3-thiazole-2-amines as tubulin inhibitors with potent antiproliferative activity

A series of N,4-diaryl-1,3-thiazole-2-amines containing three aromatic rings with an amino linker were designed and synthesized as tubulin inhibitors and evaluated for their antiproliferative activity in three human cancer cell lines. Most of the target compounds displayed moderate antiproliferative...

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Vydáno v:PLoS One
Hlavní autoři: Sun, Maolin, Xu, Qile, Xu, Jingwen, Wu, Yue, Wang, Yueting, Zuo, Daiying, Guan, Qi, Bao, Kai, Wang, Jian, Wu, Yingliang, Zhang, Weige
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2017
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5363846/
https://ncbi.nlm.nih.gov/pubmed/28333984
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0174006
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