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Sequence-Specific Regulation of Endocytic Lifetimes Modulates Arrestin-Mediated Signaling at the µ Opioid Receptor
Functional selectivity at the µ opioid receptor (µR), a prototypical G-protein–coupled receptor that is a physiologically relevant target for endogenous opioid neurotransmitters and analgesics, has been a major focus for drug discovery in the recent past. Functional selectivity is a cumulative effec...
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| Veröffentlicht in: | Mol Pharmacol |
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| Hauptverfasser: | , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
The American Society for Pharmacology and Experimental Therapeutics
2017
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5363713/ https://ncbi.nlm.nih.gov/pubmed/28153854 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.116.106633 |
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