Sequence-Specific Regulation of Endocytic Lifetimes Modulates Arrestin-Mediated Signaling at the µ Opioid Receptor

Functional selectivity at the µ opioid receptor (µR), a prototypical G-protein–coupled receptor that is a physiologically relevant target for endogenous opioid neurotransmitters and analgesics, has been a major focus for drug discovery in the recent past. Functional selectivity is a cumulative effec...

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Udgivet i:Mol Pharmacol
Main Authors: Weinberg, Zara Y., Zajac, Amanda S., Phan, Tiffany, Shiwarski, Daniel J., Puthenveedu, Manojkumar A.
Format: Artigo
Sprog:Inglês
Udgivet: The American Society for Pharmacology and Experimental Therapeutics 2017
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Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5363713/
https://ncbi.nlm.nih.gov/pubmed/28153854
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.116.106633
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