Transposon-mediated generation of BCR-ABL1-expressing transgenic cell lines for unbiased sensitivity testing of tyrosine kinase inhibitors

Point mutations in the ABL1 kinase domain are an important mechanism of resistance to tyrosine kinase inhibitors (TKI) in BCR-ABL1-positive and, as recently shown, BCR-ABL1-like leukemias. The cell line Ba/F3 lentivirally transduced with mutant BCR-ABL1 constructs is widely used for in vitro sensiti...

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Kaydedildi:
Detaylı Bibliyografya
Yayımlandı:Oncotarget
Asıl Yazarlar: Byrgazov, Konstantin, Lucini, Chantal Blanche, Berkowitsch, Bettina, Koenig, Margit, Haas, Oskar A., Hoermann, Gregor, Valent, Peter, Lion, Thomas
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Impact Journals LLC 2016
Konular:
Research Paper
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5363645/
https://ncbi.nlm.nih.gov/pubmed/27801667
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.12943
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