Transposon-mediated generation of BCR-ABL1-expressing transgenic cell lines for unbiased sensitivity testing of tyrosine kinase inhibitors

Point mutations in the ABL1 kinase domain are an important mechanism of resistance to tyrosine kinase inhibitors (TKI) in BCR-ABL1-positive and, as recently shown, BCR-ABL1-like leukemias. The cell line Ba/F3 lentivirally transduced with mutant BCR-ABL1 constructs is widely used for in vitro sensiti...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Byrgazov, Konstantin, Lucini, Chantal Blanche, Berkowitsch, Bettina, Koenig, Margit, Haas, Oskar A., Hoermann, Gregor, Valent, Peter, Lion, Thomas
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2016
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5363645/
https://ncbi.nlm.nih.gov/pubmed/27801667
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.12943
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