Overexpression of PKM2 promotes mitochondrial fusion through attenuated p53 stability

M2-type pyruvate kinase (PKM2) contributes to the Warburg effect. However, it remains unknown as to whether PKM2 has an inhibitory effect on mitochondrial function. We report in this work that PKM2 overexpression inhibits the expression of Drp1 and results in the mitochondrial fusion. The ATP produc...

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Veröffentlicht in:Oncotarget
Hauptverfasser: Wu, Haili, Yang, Peng, Hu, Wanglai, Wang, Yingying, Lu, Yangxu, Zhang, Lichao, Fan, Yongsheng, Xiao, Hong, Li, Zhuoyu
Format: Artigo
Sprache:Inglês
Veröffentlicht: Impact Journals LLC 2016
Schlagworte:
Research Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5363644/
https://ncbi.nlm.nih.gov/pubmed/27801666
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.12942
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