Mitochondrial PKM2 regulates oxidative stress-induced apoptosis by stabilizing Bcl2

Pyruvate kinase M2 isoform (PKM2) catalyzes the last step of glycolysis and plays an important role in tumor cell proliferation. Recent studies have reported that PKM2 also regulates apoptosis. However, the mechanisms underlying such a role of PKM2 remain elusive. Here we show that PKM2 translocates...

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Kaydedildi:
Detaylı Bibliyografya
Yayımlandı:Cell Res
Asıl Yazarlar: Liang, Ji, Cao, Ruixiu, Wang, Xiongjun, Zhang, Yajuan, Wang, Pan, Gao, Hong, Li, Chen, Yang, Fan, Zeng, Rong, Wei, Ping, Li, Dawei, Li, Wenfeng, Yang, Weiwei
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Nature Publishing Group 2017
Konular:
Original Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5339831/
https://ncbi.nlm.nih.gov/pubmed/28035139
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cr.2016.159
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