Mitochondrial PKM2 regulates oxidative stress-induced apoptosis by stabilizing Bcl2

Pyruvate kinase M2 isoform (PKM2) catalyzes the last step of glycolysis and plays an important role in tumor cell proliferation. Recent studies have reported that PKM2 also regulates apoptosis. However, the mechanisms underlying such a role of PKM2 remain elusive. Here we show that PKM2 translocates...

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Detalhes bibliográficos
Publicado no:Cell Res
Main Authors: Liang, Ji, Cao, Ruixiu, Wang, Xiongjun, Zhang, Yajuan, Wang, Pan, Gao, Hong, Li, Chen, Yang, Fan, Zeng, Rong, Wei, Ping, Li, Dawei, Li, Wenfeng, Yang, Weiwei
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2017
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5339831/
https://ncbi.nlm.nih.gov/pubmed/28035139
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cr.2016.159
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