Overexpression of PKM2 promotes mitochondrial fusion through attenuated p53 stability

M2-type pyruvate kinase (PKM2) contributes to the Warburg effect. However, it remains unknown as to whether PKM2 has an inhibitory effect on mitochondrial function. We report in this work that PKM2 overexpression inhibits the expression of Drp1 and results in the mitochondrial fusion. The ATP produc...

Popoln opis

Shranjeno v:
Bibliografske podrobnosti
izdano v:Oncotarget
Main Authors: Wu, Haili, Yang, Peng, Hu, Wanglai, Wang, Yingying, Lu, Yangxu, Zhang, Lichao, Fan, Yongsheng, Xiao, Hong, Li, Zhuoyu
Format: Artigo
Jezik:Inglês
Izdano: Impact Journals LLC 2016
Teme:
Research Paper
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5363644/
https://ncbi.nlm.nih.gov/pubmed/27801666
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.12942
Oznake: Označite
Brez oznak, prvi označite!

Podobne knjige/članki