MiR-106b-mediated Mfn2 suppression is critical for PKM2 induced mitochondrial fusion

Cancer cells preferentially metabolize glucose through aerobic glycolysis. This phenomenon, known as the Warburg effect, is a characteristic of glucose metabolism in cancer cells. PKM2 is reported to imply an important role in glycolysis. However, whether and how PKM2 can cause mitochondrial dysfunc...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Am J Cancer Res
Main Authors: Wu, Haili, Li, Zhuoyu, Wang, Yingying, Yang, Peng, Li, Zongrui, Li, Hanqing, Wu, Changxin
Format: Artigo
Jezik:Inglês
Izdano: e-Century Publishing Corporation 2016
Teme:
Original Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5088287/
https://ncbi.nlm.nih.gov/pubmed/27822413
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