Reduced PAK1 activity sensitizes FA/BRCA-proficient breast cancer cells to PARP inhibition

Cells that are deficient in homologous recombination, such as those that have mutations in any of the Fanconi Anemia (FA)/BRCA genes, are hypersensitive to inhibition of poly(ADP-ribose) polymerase (PARP). However, FA/BRCA-deficient tumors represent a small fraction of breast cancers, which might re...

Descrizione completa

Salvato in:
Dettagli Bibliografici
Pubblicato in:Oncotarget
Autori principali: Cruz, Olga Villamar, Prudnikova, Tatiana Y., Araiza-Olivera, Daniela, Perez-Plasencia, Carlos, Johnson, Neil, Bernhardy, Andrea J., Slifker, Michael, Renner, Catherine, Chernoff, Jonathan, Arias, Luis E.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Impact Journals LLC 2016
Soggetti:
Research Paper
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5363532/
https://ncbi.nlm.nih.gov/pubmed/27740936
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.12576
Tags: Aggiungi Tag
Nessun Tag, puoi essere il primo ad aggiungerne! !

Documenti analoghi