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The Group I Pak inhibitor Frax-1036 sensitizes 11q13-amplified ovarian cancer cells to the cytotoxic effects of Rottlerin
The p21-activated kinases (PAKs) are Cdc42/Rac–activated serine-threonine protein kinases that regulate several key cancer-relevant signaling pathways, such as the Mek/Erk, PI3K/Akt, and Wnt/β–catenin cascades. Pak1 is frequently overexpressed and/or hyperactivated in different human cancers, includ...
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| Publicado en: | Small GTPases |
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| Main Authors: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
Taylor & Francis
2016
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5680705/ https://ncbi.nlm.nih.gov/pubmed/27427770 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/21541248.2016.1213089 |
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