Reduced PAK1 activity sensitizes FA/BRCA-proficient breast cancer cells to PARP inhibition

Cells that are deficient in homologous recombination, such as those that have mutations in any of the Fanconi Anemia (FA)/BRCA genes, are hypersensitive to inhibition of poly(ADP-ribose) polymerase (PARP). However, FA/BRCA-deficient tumors represent a small fraction of breast cancers, which might re...

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Vydáno v:Oncotarget
Hlavní autoři: Cruz, Olga Villamar, Prudnikova, Tatiana Y., Araiza-Olivera, Daniela, Perez-Plasencia, Carlos, Johnson, Neil, Bernhardy, Andrea J., Slifker, Michael, Renner, Catherine, Chernoff, Jonathan, Arias, Luis E.
Médium: Artigo
Jazyk:Inglês
Vydáno: Impact Journals LLC 2016
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Research Paper
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5363532/
https://ncbi.nlm.nih.gov/pubmed/27740936
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.12576
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