CRISPR/Cas9 Editing of the Mutant Huntingtin Allele In Vitro and In Vivo

Huntington disease (HD) is a fatal dominantly inherited neurodegenerative disorder caused by CAG repeat expansion (>36 repeats) within the first exon of the huntingtin gene. Although mutant huntingtin (mHTT) is ubiquitously expressed, the brain shows robust and early degeneration. Current RNA int...

Fuld beskrivelse

Na minha lista:
Bibliografiske detaljer
Udgivet i:Mol Ther
Main Authors: Monteys, Alex Mas, Ebanks, Shauna A., Keiser, Megan S., Davidson, Beverly L.
Format: Artigo
Sprog:Inglês
Udgivet: American Society of Gene & Cell Therapy 2017
Fag:
Original Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5363210/
https://ncbi.nlm.nih.gov/pubmed/28129107
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ymthe.2016.11.010
Tags: Tilføj Tag
Ingen Tags, Vær først til at tagge denne postø!

Lignende værker