Calcium dysregulation, functional calpainopathy, and endoplasmic reticulum stress in sporadic inclusion body myositis

Sporadic inclusion body myositis (IBM) is the most common primary myopathy in the elderly, but its pathoetiology is still unclear. Perturbed myocellular calcium (Ca(2+)) homeostasis can exacerbate many of the factors proposed to mediate muscle degeneration in IBM, such as mitochondrial dysfunction,...

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Detalhes bibliográficos
Publicado no:Acta Neuropathol Commun
Main Authors: Amici, David R., Pinal-Fernandez, Iago, Mázala, Davi A. G., Lloyd, Thomas E., Corse, Andrea M., Christopher-Stine, Lisa, Mammen, Andrew L., Chin, Eva R.
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2017
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5363023/
https://ncbi.nlm.nih.gov/pubmed/28330496
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40478-017-0427-7
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