Calcium dysregulation, functional calpainopathy, and endoplasmic reticulum stress in sporadic inclusion body myositis

Sporadic inclusion body myositis (IBM) is the most common primary myopathy in the elderly, but its pathoetiology is still unclear. Perturbed myocellular calcium (Ca(2+)) homeostasis can exacerbate many of the factors proposed to mediate muscle degeneration in IBM, such as mitochondrial dysfunction,...

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Bibliografiska uppgifter
I publikationen:Acta Neuropathol Commun
Huvudupphovsmän: Amici, David R., Pinal-Fernandez, Iago, Mázala, Davi A. G., Lloyd, Thomas E., Corse, Andrea M., Christopher-Stine, Lisa, Mammen, Andrew L., Chin, Eva R.
Materialtyp: Artigo
Språk:Inglês
Publicerad: BioMed Central 2017
Ämnen:
Research
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC5363023/
https://ncbi.nlm.nih.gov/pubmed/28330496
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40478-017-0427-7
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